Introduction about GIST in special gastric GIST
Gastrointestinal Stromal Tumor (GIST) is a soft tissue sarcoma, which grows as a loose tissue or across the gastrointestinal (GI) track. The tumor is not common with an account of below 1 percent of GI tumors although it is the most common of mesenchymal neoplasmas that affects the GI tract (Menge 335; Corless 19). The sarcoma can occur anywhere along the GI, but it is common in the stomach and small intestine. The tumor varies in characteristics depending on the location, size and cell division. The size can vary between 4 mm and 35 cm (Menge 335). The characteristics determine whether the GIST expands to other areas of the body. GIST occurs in the interstitial cells of Cajal (ICC) also called the "pacemakers" (Ma 300; Al-Shboul 3) The cells belong to the nervous system known as an autonomic nervous system, which is responsible for regulating processes of the body like food digestion. ICCs signal the GI to contract and relax the muscles to allow food and other liquids flow (Klein 1635).
Although there is no much about the risk factors of GIST, it affects most old people between 40 and 80 years (Kramer 57). Also, there is a rare un inherited risk factor, a gene mutation with chances of developing GIST. Another risk factor is the primary familial GIST syndrome, a condition that is inherited (Menge 338). The syndrome can lead to the development of GIST at an early age than the expected 40 and in more than one form. Primary familial GIST syndrome originates from KIT, an abnormal gene that a child gets from parents (Zhu 4289). The abnormal gene is found in all cells of those people who inherit it but in cancer cells for those with sporadic GIST. The syndrome can also result from a change in the PDGFRA gene (Boikos 925; Astolfi 892). Another risk factor to GIST is the Neurofibromatosis type 1 disease which results from the defection of the NF1 gene, and it can be inherited (Menge 337; Al-Shboul 3). Carney-Stratakis syndrome, an inherited condition also risks the development of GIST at early ages.
Symptoms of Special Gastric GIST
Some of the symptoms, which may suggest that a person has GIST, include upper abdominal pain, abdominal fullness, nausea, heartburn or an early feeling of being full than expected (Menge 338; Zebary 560) Also, a patient may have blood on the stool or experience acute hematemesis.
Doctor’s Exclusion of more Common Cause and Think in GIST from the Symptoms
Abdominal pain, feeling of early fullness and abdominal fullness may result from the insensitivity of the ICCs. The cells may become unable to regulate the gastric activities leading to hardening of the walls, which makes one feel pain or even full. Also, one may feel full early than usual because the GI is not allowing food to flow in the
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