Answer case study question also base on this criteria with the case study disease Case Study, Chapter 29, Structure and Function of the Respiratory System Brad is 45 years old and has been working as a coal cutter in a mine for the last 25 years. He likes the job because it pays well and the same mine had employed his father. Like many of his colleagues, Brad has had problems with a chronic cough. He has avoided his annual checkups for fear that he will be told he has “black lung” or coal worker’s pneumoconiosis. The disease causes fibrosis, decreased diffusing capacity, and permanent small airway dilation. In later stages, pulmonary capillaries, alveoli, and airways are destroyed 1. How can the disease described above create a mismatch between ventilation and perfusion? Use your understanding of alveolar dead space and physiologic shunt to explain your answer. 2. Individuals with chronic obstructive pulmonary disease have more difficulty exhaling than inhaling. Why is this so? 3. In general terms, what mechanisms in lung disease can affect diffusing capacity across alveolar membranes? Use the Fick law to explain your answer. case study criteria – Presents the major pathological concepts and understanding of the disease etiology (e.g. bacterial, viral, and fungal) including epidemiology. – Identifies the different facets of the pathogenesis of the disease and the subsequent concepts of altered health states that highlight the hallmark signs and symptoms of the disorder. – Analyzes the pathological change within a precise system of alteration (e.g. cell growth, body defenses, and oxygenation) with hallmark causative agents for the chosen topic. – Applies current best practice, across the life span, with citations to treatments, lab values, and diseases mechanisms. – Provides clear examples of applied evidence-based practice with implications for advanced knowledge and disease management. – Includes references. Utilizes at minimum 2 peer review journals (cannot use your course textbook). – Oral presentation flows logically with high quality slides and visual aids. – Content is accurate with a detailed synopsis and solution to disease management.