Resources: Make sure you read chapters 3 and 4 of your text, Biological Basis of Behavior (2013). How does chemicals which are foreign to your body, such as alcohol, have an effect? How does your body produce its own chemicals (neurotransmitters)? Any type of chemical whether it is natural or synthetic can have a physical effect and/or a psychological effect. These chapters explore these aspects of human behavior. In section 3.4, there is a wonderful table of drugs and their effects that I encourage you to read. This week you will have 2 options to choose from for your assignment: Option A: Evaluate one of the neurotransmitters covered in this week’s readings. Explain the role it plays in modulating responses to a drug of abuse. For example, you could choose the acetylcholine receptor system and discuss the role this neurotransmitter plays in addiction to nicotine. In addition to your evaluation of the specific neurotransmitter and its associated receptor system, provide correlation to the involved neuroanatomical structures, the contribution of genetics and environment to the development of dependence, tolerance, and addiction to this substance, as well as clinical treatment interventions. Option B: Evaluate one of the neurotransmitters covered in this week’s readings. Explain the role it plays in a neurological or psychological disorder of your choice. For example, you could choose the dopaminergic system and discuss the role this neurotransmitter has in the development of schizophrenia. In addition to your evaluation of the specific neurotransmitter and its associated receptor system, provide a correlation to the involved neuroanatomical structures, as well as the contribution of genetics and environment to the development and clinical management of this disorder. Required Resources Required Text 1. Read from your course text, Biological basis of behavior: a. Chapter 3: Neurotransmitters and Related Drugs This chapter examines neurotransmitters families, their biosynthesis and physiologic actions, and their relation to human behavior. b. Chapter 4: The Organization of the Nervous System This chapter includes topics on central and peripheral nervous system structures and their associated functions. Book 1. American Psychiatric Association. (2013). The Diagnostic and Statistical Manual of Mental Disorders. (5th ed.). Washington, D.C.: American Psychiatric Publishing. o This is the manual of psychiatric diagnostic criteria used by mental health professionals. Multimedia 1. Gardner, E. T. (Executive producer). (1998) Brain and nervous system: Your information superhighway [Video file]. Retrieved from the Films On Demand database. o This video provides information on the topic of neurotransmitters and functional pathways in the human brain. 2. Gau, J. (Executive producer), & Weitz, M. (Director). (1984). The nervous system: Nerves at work [Video file]. Retrieved from Films On Demand. o This video provides an overview of neurons and their cellular activity as the foundation of nervous system function. 3. Intelecom. (n.d.). The influence of neurotransmitters (Links to an external site.)Links to an external site. [Video file]. Retrieved from http://searchcenter.intelecomonline.net/playClip.aspx?fromSearch=true&searchTerm=The+influence+of+neurotransmitters+&fromMyClips=false&id=awinSfNzL00NzLD6exXHNzL&ssp=-128&lid=23595865 o This video provides an overview of neurotransmitter activity in the human nervous system. Recommended Resources Articles 1. Cunha, C., Monfils, M. H., & LeDoux, J. E. (2010). GABAc receptors in the lateral amygdala: A possible novel target for the treatment of fear and anxiety disorders? (Links to an external site.)Links to an external site. Frontiers in Behavioral Neuroscience, 4(6), 1-9. Retrieved from http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841484/ o This article provides a discussion of neurotransmitters and receptors in the amygdala that related to human fear behaviors and anxiety disorders. 2. Lopez-Moreno, J. A., Gonzalez-Cuevas, G., Moreno, G., & Navarro, M. (2008). The pharmacology of the endocannabinoid system: Functional and structural interactions with other neurotransmitter systems and their repercussions in behavioral addiction (Links to an external site.)Links to an external site.. Addiction Biology, 13(2), 160-187. Retrieved from http://www.utdallas.edu/~tres/plasticity2009/Lopez-Moreno.pdf o This article provides a discussion of neurotransmitters and receptors of the endocannabinoid system in relation to behavioral addiction. Multimedia 1. Genetic Science Learning Center . (2013). Mouse party (Links to an external site.)Links to an external site. [Interactive game]. Learn. Genetics. Retrieved from http://learn.genetics.utah.edu/content/addiction/drugs/mouse.html o This learning object provides a discussion of selected psychoactive substances and their physiologic action in the nervous system.