Sex-specific vulnerabilities in alcohol-dependent Persons – Article Critique

Sex-specific vulnerabilities in alcohol-dependent Persons – Article Critique

Article One

Purpose of the Study

The authors identify and state the purpose of the study, which is twofold: to approximate sex-specific vulnerabilities of an exhaustive range of somatic conditions in alcohol-dependent (AD) persons versus a control group and, within the same cohort, to approximate sex-specific vulnerabilities to mortality from the studies somatic conditions (Becker, Holst, Sørensen, &Tolstrup, 2017).


The researchers preferred a register-oriented matched cohort design to conduct the inquiry and structure their approach.

Participant Information and Data Collection

In conformity with the principles of a cohort study, the authors relied on the Copenhagen Alcohol Cohort, the Danish Civil Registration System, the Cause of Death Registry, and the Danish National Patient Registry to identify AD persons and select the control population (Becker et al., 2017). Specifically, the Danish Civil Registration System was the source of the control group while the Danish National Patient Registry and Cause of Death Registry provided data about somatic diseases and causes of mortality, respectively (Becker et al., 2017). Using participants' identification numbers (PINs) and the Cox proportional hazards framework, the researchers linked all the registries mentioned above and measured hazard ratios (HRs). AD participants were selected from the Copenhagen Alcohol Cohort and dovetailed with the Danish Civil Registration System, thus facilitating the constitution of a control group from the wider Danish populace (Becker et al., 2017). Finally, data on causes of death, somatic conditions, and vital status was derived.

The number of AD participants was 19,002(14 091 male and 4911 female) while that of the control group was 186,767 (Becker et al., 2017). There was no room for selection bias as the researchers employed some filters to arrive at the final number of respondents automatically. Some of these included: only the initial registration for people with several records, people diagnosed with alcohol dependence based on revisions 8 or 10 of ICD,and exclusion of people whose dates of birth and death were earlier than 1 January 1927 and 1 January 1977 respectively, thereby ensuring respondents were not

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